Life-science R&D and manufacturing · Kawasaki, Japan
Three original technologies. Patented in the U.S., Japan and China.
MediScience Espoir was founded in 2004 by a physician and pharmacist from vaccine research. We develop gas–liquid fusion, nano-metal stabilization and liposome delivery technologies, make our own products with them, and license them to partners worldwide.
WOX® oxygen delivery water · 500 mL · Ingredients: water, oxygen
Research · In-house laboratory
Products · WOX® range
Patents · Japan, U.S., China
Skin care · CORGRACE®
Outreach · Research lectures
Intellectual property
Protected in the United States, Japan and China.
Our core substance, oxygen clathrate hydrate, holds substance patents in all three jurisdictions. Separate patents cover the device that makes it and the method that measures it. A substance patent in the United States is regarded internationally as one of the most demanding to obtain.
Substance patent certificates. Left to right: Japan, United States, China.
United States USPTO
10,913,037 B2Substance · 2021
10,018,605 B2Measurement method
9,943,815 B2Manufacturing device
Japan JPO
7087235Substance · 2022
6367519Manufacturing / measurement
6527161Manufacturing / measurement
China CNIPA
ZL 2015 8 0071029.1Substance · 2021
ZL 2015 8 0042784.7Measurement method
20+
patents granted across our three technologies since 2004
3
substance patents for oxygen clathrate hydrate: U.S., China, Japan
2011
first WOX® production. Four generations of manufacturing units since.
Platform technologies
Built in-house. Licensable.
Each technology began as a problem in vaccine and drug-delivery research. Each is now in commercial products, and each can be built into yours.
Gas–liquid fusionWOX®
Oxygen held in water
Binds oxygen inside a lattice of water molecules. Dissolved oxygen stays above 50 ppm, and the water can be frozen or boiled.
In use: WOX® beverages · CORGRACE® skincare · WOX400 ingredient
WOX is oxygen and water, nothing else. What makes it different is how the oxygen is held: inside a structure of water molecules, where it does not react with other components.
Fig. 1 · Oxygen clathrate hydrate512 cage 20 H₂O · 1 O₂O₂ held inside a lattice of water molecules. Schematic.US 10,913,037 B2 · JP 7087235 · CN ZL 2015 8 0071029.1
Conventional oxygen water
WOX®
How oxygen is held
Dissolved gas or nanobubbles
Oxygen clathrate hydrate: O₂ inside a lattice of water molecules
After opening
Most of the oxygen escapes soon after the bottle is opened
Dissolved oxygen stable above 50 ppm
Heat and cold
Not designed for processing
Can be frozen or boiled, so it can be used in food production
Intellectual property
—
Substance, manufacturing and measurement patents
Research
Studied in people. Published in full.
Three human studies of WOX have been published in peer-reviewed Japanese journals. We list the design and the limits with every result.
2020Prog Med 40
Randomized, placebo-controlled, double-blind crossover study
n = 12 healthy adults · 125 mL · 60 s
Capillary blood-flow velocity was higher after WOX than after placebo water at 30 and 60 seconds. Blood-oxygen saturation did not differ from placebo.
Small sample, one-minute window.
2016Prog Med 36
Open-label field test in three sessions
n = 68 adults · 150–200 mL · 1–3 min
SpO₂ rose in 56 of 68 participants. Two commercial oxygen waters labelled 120 and 150 ppm produced no change in the same setting.
Not blinded, no placebo.
2022Jpn J Mt Med 42
Field study at the summit of Mt. Fuji
n = 9 healthy adults · 500 mL · 45 min
Average SpO₂ rose about 2.5 points within five minutes; pulse rate fell over the following half hour.
No control group.
Studies were conducted in Japan by researchers affiliated with MediScience Espoir or its research nonprofit, the QOL Support Research Council. Full papers are available on request.
Progress in Medicine, 2020
Progress in Medicine, 2016
In use in JapanTEAM WOX, road race
Chosen by professional athletes in Japan.
Cycling, golf, sumo and football. Athletes in Japan drink WOX around training, and our TEAM WOX program has supported sport since 2014.
Track cycling
Golf
Sumo
Football
WOX TREE · Application map
One platform. Five industries.
Gas–liquid fusion is a foundation that other products can grow from. These are the fields where we see it improving existing products, through licensing or as a supplied ingredient.
Medical
Eye drops
Cell culture media
Nebulizer solutions
Creams, liquids, gels
Drinking liquid for medicines
Health food
Supplements
Jelly
Drinks
Food
Jelly, ice cream
Beverages
Food ingredients
Liquor
Cosmetics
Lotion, cream, essence
Gel, soap, pack
Cleansing
Toothpaste, wet tissue
Agriculture & environment
Pets and livestock
Agriculture, forestry, fisheries
Environmental improvement
Other manufacturing
Work with us
Bring our technology into your product.
If your product serves athletic performance, wellness, skin care or hygiene, one of our technologies may improve it. Samples are available to business partners.
Technology licensing
License gas–liquid fusion, nano-silver stabilization or liposome delivery for your own manufacturing.
OEM manufacturing
Formulation and production of cosmetics and quasi-drugs under our Japanese licenses.
Ingredient supply
WOX400 for cosmetics and food, oxygen liposome for cosmetics, HT Silver.
Distribution
Import and distribute WOX® and CORGRACE® products in your market.
WOX exhibition booth, Japan
Bottled and cased in Japan
From the founder
“As researchers and developers working to improve quality of life for everyone, we create new products and new substances with technology we develop in-house.”
Takaaki Matsumoto, MD, PhD, PharmacistFounder and Representative Director
Company
Manufacturing
Ingredient