MediScience Espoir Inc. · Kawasaki, Japan · Est. 2004

Home / Technology

Technology

Three platform technologies, each developed in-house from vaccine and drug-delivery research, each protected by patents and in commercial production.

Takaaki Matsumoto at the microscope
Takaaki Matsumoto, MD, PhD, in the laboratory.
Gas–liquid fusion · WOX®

A new substance: oxygen held inside water.

The WOX process binds O₂ molecules inside a lattice of water molecules. The result is a substance in its own right, oxygen clathrate hydrate, granted substance patents in the United States and China in 2021 and in Japan in 2022.

Because the oxygen is held rather than dispersed, it does not escape when the bottle is opened and it does not react with other components. WOX is designed to be taken in with water through the digestive tract, a route to oxygen intake other than the lungs.

WOX stays stable at high and low temperatures, which opens it to a wide range of products and industries.

SubstanceOxygen clathrate hydrate
IngredientsWater, oxygen
Dissolved oxygenStable above 50 ppm
TemperatureCan be frozen or boiled
ProductionWOX® manufacturing units No. 1–4, 2015–2024
Substance patentsUS 10,913,037 B2 · JP 7087235 · CN ZL 2015 8 0071029.1
Fig. 2 · Clathrate cage Schematic
not to scale
Water molecules (grey) hydrogen-bonded around one O₂ (red).Gas–liquid fusion
Three WOX bottles side by side
Beverages · WOX® range
CORGRACE WOX-sui mist bottles
Skin care · CORGRACE® WOX-sui
WOX 8 L dispenser
Offices and facilities · WOX® 8 L dispenser

Sports and active lifestyles

Used by professional athletes in Japan around training. Placebo-controlled research on blood flow and SpO₂ is published.

Skin care

WOX is the base of our CORGRACE® mists, masks and creams, delivering oxygen and moisture to the skin.

Food and beverage

Stable through freezing and heating, so it can be used as an ingredient in food production.

Life-science research

Early work on oxygenated water in cell culture and pharmaceutical development, including vaccines.

HT Silver 10 spray bottle
HT Silver 10
HT Silver spray on a living-room table
For everyday use at home
Nano-metal stabilization · HT Silver

Clean without alcohol or harsh chemicals.

HT Silver keeps nano-silver stable in water, so it does not discolor or lose effect. The result is an antibacterial, antiviral and antifungal solution that contains no alcohol.

Frequent use of alcohol sanitizers or harsh soaps leaves hands dry and rough. HT Silver is gentle enough for everyday use on skin, and it does not rust metal or damage plastic, paint, wood or varnish.

PerformanceAntibacterial, antiviral, antifungal
AlcoholNone
SurfacesSkin, metal, plastic, painted surfaces, wood, upholstery
SettingsHomes, gyms, schools, clinics
Also used asPreservative alternative in skincare
Liposome delivery · 4DDS

From skin-applied vaccines to skin care.

Our founder helped develop a vaccine that could be applied to the skin instead of injected. The same delivery science became 4DDS, a four-dimensional delivery system that carries ingredients to where they are needed and releases them gradually.

4DDS is a special liposome with a positively charged protein surface. Active ingredients sit in separate layers and are released one layer at a time, from the outside in, so they keep reaching the target area.

  1. 2008Fourth-generation liposome, CORGRACE® series
  2. 2015Fifth-generation liposome
  3. 2025Oxygen liposome ingredient
Layer 1 · released first Layer 2 Layer 3 Core · released last + CHARGED PROTEIN SURFACE
4DDS liposome, cross-section. Schematic.
CORGRACE Vector Pack
CORGRACE® Vector Pack
CORGRACE Inner Marine Moisture Cream
CORGRACE® Inner Marine Moisture Cream
CORGRACE Bright C Essence
CORGRACE® Bright C Essence
Measurement · US 10,018,605 B2

Measuring oxygen that ordinary meters miss.

Standard dissolved-oxygen meters measure free oxygen. Oxygen held in clathrate form does not fully register, so conventional instruments undercount it.

We developed and patented a total dissolved-oxygen method that releases and measures the held oxygen. Every WOX specification is stated on this basis, and the method is patented in the United States, Japan and China.

United States patent certificate
United States patent certificate.

Looking for a technology partner in Japan?

Licensing, OEM and ingredient supply for partners worldwide.

Contact our team →